Pakistani-Americans or American-Pakistanis?

Re: # 83
Paki...

The jewish immigration and Paki immigration is different matter all together. The jewish migrants left no baggage for the country they left (mostly europe) and they have provided the intellectual backbone of USA. Majority of christians have no problem with jews ( theological reason)....

Re: # 146
Majumder....
They need at least 50 US Jinnahs to make it into 50 pieces...but before that, they have de-humanize (or beduinize) americans....big task, no doubt.....

Re: # 130
Dawa Deal....
What is wrong in enjoying better life style in USA and adopting their culture? The best option for any individual is to learn from who is better and adopt it locally. That is the way human civilisation progresses....
If all Pakis live in Pakiland and stops interacting withj civilised world, entire Pakiland will be arab beduinised with its 7th century baggage of Shariat, Hadith , Korun etc... and if you try to implement these teaching (kill infidels...) you will see rain of hellfires and brahmos(missiles) from east and west...
BTW, your defence hero has stolen the nuclear arms technology from europe.....So, you would not have those nuke bombs (or chinese made nukes) to defend the land of pure....

Re: # 82
Paki....
So the jobs transferred to India from USA and Europe is by Indian CEOs!!!!

IBM, HP, Accenture, Intel, Del, CA, EDS, EMC2, Symmantec, Google, GE, GM, AMD, Samsung, Motorola, CISCO, Microsoft....hardly one or two members of the executive commitee is Indian.....Who has stopped Pakis from replicating such model?

One more suggestion....
India is now prominant destination of medical tourism. Indian doctors trained in USA and Europe is now opening good quality infrastructure in healthcare segment. Those who can afford it, can avail it. The revenue generated from foreign patients are used to subsidise treatment for poors...

Re: # 145
Dawa....
Pakistan was created from a breaking process (separatist agenda), so Pakistan may keep on disintegrating.....

USA was created by integrating separate states and so, they have kept on adding states (Hawai, Alaska...)....

So, no day dreaming, rather prey to arabic moon god and his sacred sons (arab beduines) to help Pakistan keep it integrated....

All 3rd class citizens..identyless countryless..mummy daddy US Pako blend....have nothing of thier own...food..clothes..shoes..house...pays..fees...cars..everthing on interest...sood..credit cards..and loans....


Prophet Muhammad(pbuh) said:

Thre are 72 levels of a interest ..and lightest level is just like equal to do adultery with one's own real Mother !

All 3rd class citizens..identyless countryless..mummy daddy US Pako blend....have nothing of thier own...food..clothes..shoes..house...pays..fees...cars..everthing on interest...sood..credit cards..and loans....


Prphet Muhammad(pbuh) said:

Thre are 72 levels of a interest ..and lightest is just like equal to do adultery with one's own real Mother !

Dawa behen,

We 160 million Pakistanis are waiting anxiously when US will break in 50 pieces...

Maybe one of these Pak Am doctors will emerge as the American Jinnah (pbuh).

Regards

We 160 million Pakistanis are waiting anxiously when US will break in 50 pieces...

When titanic of its interest based economy sink atlast...

i want to see the same hunger and poverrty in US which i see in Asia and Africa...which is solely created by IMF WB etc etc...

By the way..3rd class citizens are jumping up and down alot...

Dr. Afia is also an american citizen...

where your bloody country and its bloody courts

where is your bloody honour of justice..courts..and human rights dramaibazi

Whitehead brings new dimension to cancer research
Alyssa Kneller , Whitehead Institute
July 12, 2006


New research at MIT may lead the pharmaceutical industry to take a whole new approach to battling the spread of cancer.

Cancer spreads when a cell breaks away from a primary tumor, settles in a new location and once again divides -- a process known as metastasis.

Pharmaceutical companies evaluating anti-cancer therapeutics typically use simplistic two-dimensional assays, or tests, to measure success in stopping metastasis. In these assays, cells crawl across the surface of a matrix, traveling in a single plane. A new MIT study indicates that this common approach for evaluating anti-cancer therapeutics misses some crucial phenomena.

Working in the labs of Whitehead member and MIT Professor Paul Matsudaira and MIT Professor Douglas Lauffenburger, postdoctoral researcher Muhammad Zaman discovered that cells move quite differently in three dimensions. His study, which focused on human prostate tumor cells, appeared the week of July 10 in the online early edition of Proceedings of the National Academy of Sciences.

"Two-dimensional assays ignore the obstacles that cells face in their natural contexts," said Zaman, who recently became an assistant professor at the University of Texas at Austin. "In 3-D, cells move through a thick jungle of fibers, or 'vines,' that hinder forward progress."

Cells must either squeeze through or chop up these putative vines to get anywhere. As a result, they move more slowly in three dimensions.

In an interesting twist, all cells need at least some vines to move, as they latch onto the "branches" with claw-like proteins called integrins and pull themselves forward. When Zaman disabled some of these claws, in a manner analogous to the workings of certain anti-cancer drugs, the cells moving across the top of the jungle canopy (in two dimensions) needed a greater number of vines to keep up their pace, while cells plowing through the jungle instead needed fewer vines to maintain the same speed.

This situation is further complicated in that the cells become dramatically sensitive to the stiffness of the vines when the integrins are disabled and consequently tend to squeeze through the vines rather than pushing them aside.

"Our findings help explain why two-dimensional assays for metastasis-inhibiting drugs do not effectively predict their effects in tissue," said Lauffenburger, who is head of MIT's Biological Engineering Division. He said he believes pharmaceutical companies will eventually use three-dimensional assays, accompanied by appropriate computational models such as one reported by Zaman in a 2005 paper, to determine how drugs affect metastasis.

But technology must improve before more complicated 3-D studies are attempted. For his 3-D study, Zaman worked with one sample at a time, using a special confocal microscope at the Whitehead-MIT BioImaging Center. The microscope divided each specimen into virtual slices, generating a new stack of images every 15 minutes.

"It took me about a year to get enough data because the microscope wasn't designed for high-throughput experiments," he said. Fortunately, the BioImaging Center has one of the most powerful sets of computers at MIT and the imaging processing and analysis went quite quickly.

"Muhammad was successful for two reasons," said Matsudaira, an MIT professor of biology and biological engineering. "His computational model predicted what would happen in virtual experiments and then he was able to go straight to test the predictions with these complicated 3-D experiments. As a result, the sophisticated models of cell movement enhance our understanding of key biological processes, including metastasis."

The research was funded by the National Institutes of Health, the National Science Foundation and the Sokol Foundation for Cancer Research.

http://www.engr.utexas.edu/news/articles/200806241512/index.cfm

About the Speaker : Hamid Zaman is an Asst. Prof. in the Departments of Biomedical Engineering and Cell and Molecular Biology and member of Institute of Theoretical Chemistry as well as Institute for Computational Engineering and Sciences and of Center for Synthetic and Systems Biology at UT Austin. He obtained his PhD from the Chemistry Department at the University of Chicago, focusing on the protein folding, dynamics and interactions. His current research focuses on developing interdisciplinary tools to study interaction of cells with extra-cellular matrices, particularly in cancer progression and metastasis. He has developed new techniques, both theoretically and experimentally to study this problem. Hamid has and continues to publish extensively in highly prestigious international journals. His research has been recognized broadly through various international awards. In 2007, he was awarded the FEBS (Federation of European Biochemical Societies) Young Investigator Award in Matrix Biology, an award rarely given to anyone outside the European Union. Recently, he was also named International Visiting Fellow at the University of Sydney, Australia. His work on cell migration in 3D, published in the Proceedings of the National Academy of Sciences, was hailed world-wide as one of the major breakthroughs in cancer in 2006. Prior to his position at UT Austin, Hamid was Hermann and Margaret Sokol Foundation Post-Doctoral Fellow at MIT and was a Burroughs Wellcome Foundation Graduate Fellow at the University of Chicago during his Ph.D. During his undergraduate, Hamid was also the awarded Alfred Crabaugh Outstanding Senior Award, given to the best undergraduate student at the entire University. More information about Hamid’s work at UT Austin is available at zlabs.bme.utexas.edu.

Hamid Zaman is an Assistant Professor of Biomedical Engineering at SSe,LUMS,Lahore.

Khwarzimic Science Society invites ....



Seminar:

Understanding Cell Matrix Interactions: From Fundamental Thermodynamics to Applications in Tumor Metastasis


Speaker: Dr. Muhammad Hamid Zaman, The University of Texas at Austin, USA.

Venue: Institute of Biochemistry and Biotechnology, University of the Punjab, Lahore.

Time and Date: 8/5/2008 (month/day/year)

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Introduction:


Cells reside and operate in a complex and dynamic extra-cellular matrix. The mechanical, structural and chemical properties of the matrix regulate a variety of cellular functions including signaling, adhesion, migration as well as invasion and metastasis in tumor systems. Unfortunately cell-matrix interactions have traditionally been studied in the context of artificial 2D environments, which are far from in vivo conditions. As a result, our understanding of the complex interactions at the cell-matrix interface have been quite limited. In particular, the mechano-chemical effects of the matrix, the proteolytic pathways and surface receptor dynamics on a 3D surface that are critical in invasion and tumor metastasis, and can not be fully studied in a 2D environment. In order to overcome the limited powers of observation in 2D, we utilize a combination of high resolution and high throughput confocal microscopy, bulk and micro-rheological measurements and multi-scale simulations rooted in statistical and continuum mechanics. Using an interdisciplinary approach allows us to understand and quantify the mechanical and chemical roles of the matrix in regulating signaling, adhesion and motility. Our results demonstrate that both cell structure and cell function are strikingly different in 3D than in 2D and that cellular response to minor mechanical changes in its extra-cellular environment is amplified in 3D than in 2D environments. Our experimental results are complemented by multi-scale simulations, that probe the physical foundations of cell-matrix interactions from the nano to the macro level. Our hybrid approach, combining high-resolution experimental and computational techniques demonstrates how a balance of cellular parameters (e.g. integrin expression and MMP activity) co-operate with matrix properties (e.g. composition, stiffness and porosity) to regulate adhesion, invasion and motility of tumor cells in native like environments.

If he had stayed at Oxford or Berkeley for 10 to 15 years...Nobel would have not snatched from his hands.